Plastic Surgery in the department of Surgery

Clinician-Scientists

 

 

Catherine Curtin, MD, Assistant Professor in the Stanford Division of Plastic and Reconstructive Surgery is a graduate of Yale Medical School. She did her plastic surgery residency at the University of Michigan and completed her training as the Stanford Hand Fellow from 2006-2007. She also completed the Robert Wood Johnson Clinical Scholars program, a fellowship in Health Services research. Dr. Curtin has a joint appointment at Stanford and the Veterans Affairs (VA) Palo Alto Health Care System. She has a current VA funded trial assessing the impact of minocycline on postoperative pain after minor hand surgery. She also has funded research looking at quality indicators in surgery. She is associate editor for the Journal of Hand Surgery. Catherine Curtin
   

Dr. David Kahn’s research interests include evaluating how the face ages and rejuvenation techniques, functional rhinoplasty, and cosmetic and reconstructive breast surgery. He is a member of the in-service examination committee for the Plastic Surgery Educational Foundation, an associate editor of e-Plasty, and an invited reviewer for several peer review journals. He is also a member of several societies including The American Society for Aesthetic Plastic Surgery and the American Society of Plastic Surgery. Dr. Kahn was recently elected into the prestigious American Association of Plastic Surgeons.

David Kahn
   
For Derrick Wan, MD, understanding the basis for a birth defect is an important consideration when planning for surgical reconstruction. For example, Pierre Robin sequence and Treacher Collins syndrome are rare birth defects that are associated with mandibular hypoplasia. It has been hypothesized, however, that the mandible may be differentially affected. Some of our recent research focuses on comparing mandibular morphology in children with Pierre Robin sequence with children with Treacher Collins syndrome using three-dimensional analysis of computed tomographic scans. Three-dimensional mandibular morphometric analysis in patients with Pierre Robin sequence and Treacher Collins syndrome thus revealed distinctly different patterns of mandibular hypoplasia relative to normal
controls.
Derrick Wan
   
In addition to her clinical commitment, Dung Hoang Nguyen, MD, PharmD has research interests in lymphedema treatment. She has published articles in peer review journals, presented at national and international professional meetings and has authored book chapters in various plastic surgery textbooks. She also enjoys volunteering on overseas medical missions and participating in medical charity activities. Dung Hoang Nguyen
   
For Geoffrey Gurtner, MD human skin is a remarkably plastic organ that sustains insult and injury throughout life. Its ability to expeditiously repair wounds is paramount to survival and is thought to be regulated by wound components such as differentiated cells, stem cells, cytokine networks, extracellular matrix, and mechanical forces. These intrinsic regenerative pathways are integrated across different skin compartments and are being elucidated on the cellular and molecular levels. Recent advances in bioengineering and nanotechnology have allowed researchers to manipulate
these microenvironments in increasingly precise spatial and temporal scales, recapitulating key homeostatic cues that may drive regeneration. The ultimate goal is to translate these bench achievements into viable bedside therapies that address the growing global burden of acute and chronic wounds.
Geoffrey Gurtner
   
Gordon Lee, MD leads his clinical research group, where he is interested in complex microsurgical reconstructions, clinical outcomes as well basic science investigations into biomaterials, muscle stem cells, adipocyte stem cells, and composite tissue allotransplantation (CTA). As the residency program director, Dr. Lee is responsible for educating and training the next generation of plastic surgeons. Studying clinical outcomes and being on the frontier of scientific discovery allows Dr. Lee to find better ways to improve patient care and to provide the highest quality surgical procedures for his patients. Dr. Lee is also considered a leader in surgical education, and has been an invited speaker at several national meetings. He has obtained competitive grant funding for his research in microsurgical education, and has several ongoing projects incorporating innovative digital tools for surgical training. Dr. Lee serves on several peer-reviewed scientific journals, which include being the Associate Editor for the Annals of Plastic Surgery Journal’s Microsurgery Section, as well as serving on the editorial board for the Microsurgery Journal, and Plastic & Reconstructive Surgery GO (Global Open Access). Dr. Lee is Board Certified by the American Board of Plastic Surgery, Inc. and is an active member of the American Society of Plastic Surgeons (ASPS), the American Association of Plastic Surgeons (AAPS), the American Society for Reconstructive Microsurgery (ASRM), California Society of Plastic Surgeons (CSPS) and the American Council of Academic Plastic Surgeons (ACAPS). Gordon Lee
   
For H. Peter Lorenz, MD, scar formation, a physiologic process in adult wound healing, can have devastating effects for patients; a multitude of pathologic outcomes, affecting all organ systems, stems from an amplification of this process. In contrast to adult wound repair, the early-gestation fetal skin wound heals without scar formation, a phenomenon that appears to be intrinsic to fetal skin. An intensive research effort has focused on unraveling the mechanisms that underlie scarless fetal wound healing in an attempt to improve the quality of healing in both children and adults. Unique properties of fetal cells, extracellular matrix, cytokine profile, and gene expression contribute to this scarless repair. Despite the great increase in knowledge gained over the past decades, the precise mechanisms regulating scarless fetal healing remain unknown. Herein, we describe the current proposed mechanisms underlying fetal scarless wound healing in an effort to recapitulate the fetal phenotype in the postnatal environment. H. Peter Lorenz
   
Dr. James Chang’s basic science research interests include modulation of Transforming Growth Factor-Beta in scarless flexor tendon wound healing and tissue engineered flexor tendonbone grafts for hand reconstruction. He has expertise in molecular biology and tissue engineering techniques and their applications to plastic and hand surgery research. Dr. Chang is the recipient of numerous grants including multi-year Federal Merit Review Awards on “Tissue Engineered Flexor Tendon Grafts for Extremity Reconstruction” and “Optimization of Bioengineered Tendons Using Bioreactors and Stem Cells”. For this body of research, Dr. Chang received the American Society for Surgery of the Hand (ASSH) Weiland Medal for Outstanding Research Achievement in 2011. Dr. Chang teaches at Stanford on many levels. His popular sophomore seminar, Surgical Anatomy of the Hand: From
Rodin to Reconstruction, was the focal point of an exhibit at the Cantor Art Center in 2014. He has mentored over 50 Stanford medical students and is very involved in the training of plastic surgery residents and hand fellows. As C.M.O. of ReSurge (formerly Interplast), Dr. Chang manages the service and educational programs of this charitable organization that delivers reconstructive surgery to the underserved throughout the world. His current research also focuses on developing outcomes criteria and using new technology to maximize efficiency in delivering reconstructive surgery and plastic surgery education overseas.
James Chang
   
According to Jill Helms, DDS, PhD, every adult tissue harbors stem cells, which potentially could be used to regenerate damaged or diseased tissues. In my laboratory, one of our goals is to understand the regulatory pathways that control stem cell self-renewal, proliferation, and differentiation. We have focused on two signaling pathways whose activities seem to be an essential feature of tissue healing. Wnts and Hedgehog proteins are both lipid-modified growth factors that have well documentedand essential- roles in embryonic development. We have found that both pathways are active during the repair of bones, muscle, skin, heart, brain, and retina, and that repair of most or all of these tissues is impeded when these two pathways are blocked. We have developed a novel packaging method whereby the biological activity of lipidated Wnt and Hedgehog proteins can be preserved in the in vivo wound environment. Using these and other tools developed by our collaborator Roel Nusse, we have embarked on experiments to first understand the mechanisms of action of these growth factors in the healing wound, and second, to use this information in biomimetic strategies to accelerate tissue repair. Jill Helms
   
Research performed by Dr. Michael Longaker, MD, MBA focuses on the following areas: Wound repair, both fetal and adult, adiposederived stem cell biology, skeletal biology, and craniofacial development and repair. Dr. Longaker is the recipient of numerous grants from the NIH, Department of Defense, and the California Institute of Regenerative Medicine (CIRM). He has published over 1100 articles and is a member of the following surgical societies: American College of Surgeons, Plastic Surgery Research Council, Association for Academic Surgery, American Association of Plastic Surgeons, Society of University Surgeons, and the American Surgical Association. In addition, Dr. Longaker is a member of the American Society for Clinical Investigation, Association of American Physicians, and the Institute of Medicine of the National Academies. Notably, he has served as President of the Society of University Surgeons and President of the Plastic Surgery Research Council. He has received numerous awards for his research including the Flance-Karl Award from the American Surgical Association, and the Sheen Award the from the Bank of American/American College of Surgeons. Michael Longaker
   
Rohit Khosla, MD is interested in understanding the basis for a class of birth defects known as craniosynostoses, which cause premature closure of some or all of the head sutures. Children who are affected by this condition display characteristic phenotypes according to the suture or sutures involved. Restricted normal growth of the skull can lead to increased intracranial pressure and changes in brain morphology, which in turn may contribute to neurocognitive deficiency. Management has primarily focused on surgical correction of fused sutures prior to 12 months of age to optimize correction of the deformity and to ameliorate the effects of increased intracranial pressure. However, emphasis has recently shifted to better understanding the pathogenesis of neurocognitive impairment observed in these children, along with genetic mutations that contribute to premature suture fusion. We believe that this understanding will provide opportunities for earlier and more specific neurocognitive interventions and for the development of targeted genetic therapy to
prevent pathologic suture fusion.
Rohit Khosla
   
Sabine Girod, MD, DDS, PhD, focuses her research on 3D planning and clinical outcome prediction of facial surgery. Her interest in 3D simulation in craniofacial surgery is based on the clinical spectrum of her work and the difficulties associated with planning and teaching complex facial procedures. She collaborates with the computer science department in the development of new force-feedback virtual environments that will allow surgeons to simulate and rehearse surgeries. She has received numerous grants, most recently a VA Merit Grant “Advanced Visuohaptic Surgical Planning For Trauma Surgery” and her work has resulted in publication of over 60 articles and conference papers including multiple best paper awards for outstanding contribution to the field. Together with her colleagues in Computer Sciences she advises computer science graduate students and teaches a three-quarter curriculum ‘Simulation of Human Physiological & Anatomical Systems’ ‘Modeling of Molecular Systems’, and ‘Mathematical and Statistical Analysis of Medical Systems.’ Sabine Girod
   
As part of the research of Subhro Sen, MD, an in-house method was evaluated for its efficiency to detect the HIV-1 drug resistance mutations. This method was compared with the ViroSeq? Genotyping System 2.0 (Celera Diagnostics, US) a gold standard. Sixty-five stored plasma samples, previously tested for HIV-1 drug resistance using the ViroSeq? method were used to evaluate the in-house method. Out of the sixty five plasma samples, sixty were HIV-1 positive clinical samples; four samples from the Virology Quality Assessment (VQA) program and one positive control from the ViroSeq? kit were used in this study. The sequences generated by the ViroSeq? and an in-house method showed 99.5±0.5% and 99.7±0.4% (mean±SD) nucleotide and amino acid identity, respectively. Out of 214 Stanford HIVdb listed HIV-1 drug resistance mutations in the protease and reverse transcriptase regions, concordance was observed in 203 (94.9%), partial discordance in 11 (5.1%) and complete discordance was absent. The in-house primers are broadly sensitive in genotyping multiple HIV-1 group M subtypes. The amplification sensitivity of the in-house method was 1000 copies/ml. The evaluation of the in-house method provides results comparable with that of ViroSeq? method thus, making the in-house method suitable for HIV-1 drug resistance testing in the developing countries. Subhro Sen
   
A Veterans Affairs funded researcher, Vincent Hentz, MD conducts research focused on the biomechanics of hand and arm function in individuals who have suffered cervical spinal cord injury. He also is a principal investigator in several clinical trials of novel treatments for Dupuytren’s disease. Dr. Hentz has authored or co-authored six textbooks and more than 100 peer-reviewed scientific articles. He is a past president of the American Society for Surgery of the Hand and serves as Deputy Editor of the Journal of Hand Surgery. Vincent R. Hentz

 

 

 

 

 

 

 


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